Can genetics make prostate cancer screening more effective?
In this EMUC TV video, Prof. Ros Eeles explores how germline BRCA mutations and polygenic risk scores are reshaping prostate cancer early detection strategies. Drawing on findings from the IMPACT study and the BARCODE 1 study, she discusses how genetic risk stratification can identify men at greatest risk of clinically significant disease, enable more targeted screening approaches, and help reduce overdiagnosis. The video also highlights the future potential of population-based genetic testing and initiatives such as PRAISE-U to deliver personalised prostate cancer screening across Europe.