Two urologists and a radiation oncologist discuss the different treatment options for locally advanced prostate cancer based on most recent oncological and functional data. Knowledge of different techniques and complications will help to make optimal choices for and with our patients. Should adjuvant or early salvage radiotherapy be administered following biochemical recurrence after radical prostatectomy? Three published randomised controlled trials showed that adjuvant radiotherapy to the prostate bed gave better biochemical control than no adjuvant radiotherapy. However several recent trials showed no clear evidence that adjuvant radiotherapy improved event-free survival compared with early salvage radiotherapy. What is should be the standard of care for men diagnosed with locally advanced prostate cancer?