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Quality of life in men living with advanced and localised prostate cancer in the UK: a population-based study

  • Amy Downing 1,
  • Penny Wright 2,
  • Luke Hounsome 3,
  • Peter Selby 4,
  • Sarah Wilding 1,
  • Eila Watson 6,
  • Richard Wagland 7,
  • Paul Kind 8,
  • David W Donnelly 9,
  • Hugh Butcher 2,
  • James W F Catto 10,
  • William Cross 11,
  • Malcolm Mason 12,
  • Linda Sharp 13,
  • David Weller 14,
  • Galina Velikova 2,
  • Eilis McCaughan 15,
  • Rebecca Mottram 1,
  • Majorie Allen 1,
  • Therese Kearney 9,
  • Oonagh McSorley 16,
  • Dyfed W Huws 17,
  • David H Brewster 14,
  • Emma McNair 18,
  • Anna Gavin 9,
  • Adam W Glaser 19
1 Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK; Leeds Institute for Data Analytics, University of Leeds, Leeds, UK. 2 Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK 3 National Cancer Registration and Analysis Service, Public Health England, Bristol, UK 4 Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK; Leeds Teaching Hospitals NHS Trust, Leeds, UK 6 Department of Midwifery, Community and Public Health, School of Nursing and Midwifery, Oxford Brookes University, Oxford, UK 7 Faculty of Health Sciences, University of Southampton, Southampton, UK 8 Academic Unit of Health Economics, University of Leeds, Leeds, UK 9 Northern Ireland Cancer Registry, Queens University Belfast, Belfast, UK 10 Academic Urology Unit, University of Sheffield, Sheffield, UK 11 Leeds Teaching Hospitals NHS Trust, Leeds, UK 12 Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK 13 Institute for Health & Society, Newcastle University, Newcastle upon Tyne, UK 14 Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK 15 Institute of Nursing and Health Research, Ulster University, Coleraine, UK 16 School of Nursing and Midwifery, Queen's University Belfast, UK 17 Welsh Cancer Intelligence and Surveillance Unit, Public Health Wales, Cardiff, UK 18 Information Services Division, NHS National Services Scotland, Edinburgh, UK 19 Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK; Leeds Institute for Data Analytics, University of Leeds, Leeds, UK; Leeds Teaching Hospitals NHS Trust, Leeds, UK

Publication: The Lancet Oncology, January 2019

DOI: https://doi.org/10.1016/S1470-2045(18)30780-0

© 2019 Elsevier Ltd. All rights reserved.

https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(18)30780-0/fulltext

Background

Little is known about the health-related quality of life (HRQOL) of men living with advanced prostate cancer. We report population-wide functional outcomes and HRQOL in men with all stages of prostate cancer and identify implications for health-care delivery.

Methods
For this population-based study, men in the UK living 18–42 months after diagnosis of prostate cancer were identified through cancer registration data. A postal survey was administered, which contained validated measures to assess functional outcomes (urinary incontinence, urinary irritation and obstruction, bowel, sexual, and vitality and hormonal function), measured with the Expanded Prostate Cancer Index Composite short form (EPIC-26), plus questions about use of interventions for sexual dysfunction) and generic HRQOL (assessed with the 5-level EuroQol five dimensions questionnaire [EQ-5D-5L] measuring mobility, self-care, usual activities, pain or discomfort, and anxiety or depression, plus a rating of self-assessed health). Log-linear and binary logistic regression models were used to compare functional outcomes and HRQOL across diagnostic stages and self-reported treatment groups. Each model included adjustment for age, socioeconomic deprivation, and number of other long-term conditions.

Findings
35 823 (60·8%) of 58 930 men responded to the survey. Disease stage was known for 30 733 (85·8%) of 35 823 men; 19 599 (63·8%) had stage I or II, 7209 (23·4%) stage III, and 3925 (12·8%) stage IV disease. Mean adjusted EPIC-26 domain scores were high, indicating good function, except for sexual function, for which scores were much lower. Compared with men who did not receive androgen deprivation therapy, more men who received the therapy reported moderate to big problems with hot flushes (30·7% [95% CI 29·8–31·6] vs 5·4% [5·0–5·8]), low energy (29·4% [95% CI 28·6–30·3] vs 14·7% [14·2–15·3]), and weight gain (22·5%, 21·7–23·3) vs 6·9% [6·5–7·3]). Poor sexual function was common (81·0%; 95% CI 80·6–81·5), regardless of stage, and more than half of men (n=18 782 [55·8%]) were not offered any intervention to help with this condition. Overall, self-assessed health was similar in men with stage I–III disease, and although slightly reduced in those with stage IV cancer, 23·5% of men with metastatic disease reported no problems on any EQ-5D dimension.

Interpretation
Men diagnosed with advanced disease do not report substantially different HRQOL outcomes to those diagnosed with localised disease, although considerable problems with hormonal function and fatigue are reported in men treated with androgen deprivation therapy. Sexual dysfunction is common and most men are not offered helpful intervention or support. Service improvements around sexual rehabilitation and measures to reduce the effects of androgen deprivation therapy are required.

Funding
The Movember Foundation, in partnership with Prostate Cancer UK.